Summary
In 8 unanesthetized dogs, 10-21 days post pancreatectomy, the cardiac chronotropic
response to rapid infusion of a pharmacological dosage of Adrenaline was begun. During
the subsequent month, the response was recorded electrocardiographically on 19 occasions.
On 8 occasions, animals were treated with continuous intravenous administration of
fluids and insulin up to the time of the test; on 11, insulin was omitted for 18 hours
before Adrenaline injection. Insulin treated animals responded with the typical brief
initial bradycardia, followed by some 2 minutes of ventricular tachycardia, and restoration
of preinjection heart rate and electrocardiograph pattern within 5 minutes. On those
occasions when insulin was omitted, the tachycardia was replaced by ventricular bradycardia.
The altered chronotropic response of non-insulin treated dogs indicates impairment
of their cardiac beta receptors.
Key words
Diabetes - Post Pancreatectomy - Beta Receptors - Cardiac - Insulin Treatment - Intravenous
- Adrenaline - Chronotropic Response
